Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus

详细信息    查看全文

• 作者：Chan-Hee Jung¹ ; Kyu-Jin Kim¹ ; Bo-Yeon Kim ; Chul-Hee Kim ; Sung Koo Kang ; Ji-Oh Mok ; ^{hanna@schmc.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Vitamin D ; Peripheral neuropathy ; Nephropathy ; Microvascular complication ; Type 2 diabetes mellitus
• 刊名：Nutrition Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：36
• 期：2
• 页码：117-124
• 全文大小：393 K

文摘

We aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) and microvascular complications in type 2 diabetes mellitus (T2DM) patients. It was hypothesized that lower 25(OH)D would be associated with increased microvascular complications in T2DM. A total of 257 T2DM patients (111 men, 146 women) who underwent diabetic microvascular complication (peripheral neuropathy, nephropathy, retinopathy) studies were recruited. Patients were categorized into 3 groups according to vitamin D status: vitamin D sufficient (n = 41, 25[OH]D ≥ 20 ng/mL), vitamin D insufficient (n = 132, 10 ≤ 25[OH]D < 20 ng/mL), and vitamin D deficient (n = 84, 25[OH]D < 10 ng/mL). In men, the prevalence of diabetic peripheral neuropathy (DPN) was significantly higher in patients with vitamin D deficiency than in those with insufficiency or sufficiency (38%, 11.7%, and 10%, respectively; P = .005). In addition, the prevalence of diabetic nephropathy (DN) was significantly higher in women with vitamin D deficiency than in the other 2 groups (40%, 20.6%, and 0%; P = .007). Compared with men in the vitamin D–sufficient group (reference), men in the vitamin D–deficient group had an increased risk of DPN after adjusting for confounding factors (odds ratio, 7.79; 95% confidence interval, 1.52-40.05). For women, when the vitamin D–sufficient group was used as a reference, those in the vitamin D–deficient group had an increased risk of DN after adjusting for confounding factors (odds ratio, 4.27; 95% confidence interval, 1.58-11.56). This present study found that a serum 25(OH)D level less than 10 ng/mL is independently associated with increased DPN in male patients and increased DN in female patients with T2DM.