p53 participates in the protective effects of ischemic post-conditioning against OGD-reperfusion injury in primary cultured spinal cord neurons

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• 作者：Jinquan Li¹ ; Gong Chen¹ ; Xinjie Gao¹ ; Chao Shen ; Ping Zhou ; Xing Wu ; Xiaoming Che ; ^{chexiaoming@huashan.org.cn} ; Rong Xie ; ^{xierong3034@163.com}
• 关键词：OGD ; oxygen glucose deprivation ; PC ; post-conditioning ; I/R ; ischemia-reperfuison
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：129-134
• 全文大小：1337 K
• 卷排序：638

文摘

Ischemic post-conditioning (PC) has protective effects against I/R injury. MDM2-p53 pathway involves in OGD-reperfusion injury in spinal cord neurons. The protection of PC is dependent on MDM2-p53 and relates with cell apoptosis.