A new excellent antibacterial scaffold consisting of type I collagen, chitosan and nanoparticle TiO₂ in anatase form is developed.

The addition of nano-TiO₂ will form additional hydrogen bonds with collagen and chitosan, acting as a bridge between the molecular chains to increase the density of the mesh structure.

A strong hydrogen bonding is formed in the scaffold, which plays important roles in determining the overall properties and performance.

With the addition of TiO₂, such properties of the scaffolds is improved as mechanical properties, resistance to degradation, antibaterial ability. The scaffold might provide a clean and sterile environment for wound repairing.