Zinc deficiency exacerbates while zinc supplement attenuates cardiac hypertrophy in high-fat diet-induced obese mice through modulating p38 MAPK-dependent signaling
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- 作者：Shudong Wanga ; b ; Manyu Luob ; c ; Zhiguo Zhanga ; b ; Junlian Gub ; Jing Chenb ; Kristen McClung Payneb ; d ; Yi Tanb ; e ; Yuehui Wanga ; Xia Yina ; Xiang Zhangf ; Gilbert C. Liub ; Kupper Wintergerstb ; e ; Quan Liua ; Yang Zhenga ; zhengyang@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lu Caib ; e ; l0cai001@louisville.edu" class="auth_mail" title="E-mail the corresponding author ; lcai1@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zn ; zinc ; HFD ; high fat diet ; ZD ; zinc deficiency ; ZN ; zinc normal ; ZS ; zinc supplement ; ORCH ; obesity-related cardiac hypertrophy ; TNF-α ; tumor necrosis factor-alpha ; IPGTT ; intraperitoneal glucose tolerance tests ; AUC ; area under the curves ; SB ; SB203580 ; WGA ; wheat germ agglutinin ; ANP ; atrial natriuretic peptide ; BNP ; brain natriuretic peptide ; β-MHC ; β-myosin heavy chains ; IL-6 ; interleukin-6 ; MEF2c ; myocyte enhancer factor 2c ; NF-κB ; nuclear factor-κB ; GATA4 ; GATA binding factor 4
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：134-146
- 全文大小：4013 K
文摘
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Childhood obesity can lead to obesity-related cardiac hypertrophy (ORCH) in adult.
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ORCH was associated with increased cardiac inflammation and P38 MAPK activation.
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Zinc (Zn) deficiency worsened ORCH and associated P38 MAPK activation.
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Zn supplement prevented ORCH and associated P38 MAPK activation.
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Block of p38 MAPK completely abolished ORCH in mice and cardiomyocytes in vitro.