Metabolic syndrome and chronic kidney disease in a rural Chinese population

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• 作者：LiPing Jiang^a ; YuanBo Liang^b ; Bo Qiu^a ; FengHua Wang^b ; XinRong Duan^b ; XiaoHui Yang^b ; JinGang Yang^c ; Wen Huang^a ; ^{huangwen2011668@sohu.com"" rel=""nofollow} ; NingLi Wang^b ; ^{wningli@vip.163.com"" rel=""nofollow}
• 关键词：Chronic kidney disease ; Metabolic syndrome ; Epidemiology ; China
• 刊名：Clinica Chimica Acta
• 出版年：2011
• 出版时间：9 October 2011
• 年：2011
• 卷：412
• 期：21-22
• 页码：1983-1988
• 全文大小：255 K

文摘

Background

Metabolic syndrome is a common risk factor for cardiovascular disease. Chronic kidney disease (CKD) is a worldwide public health problem. We investigated the association between metabolic syndrome and CKD in a rural Chinese population.

Methods

This was a cross-sectional study using data from the Handan Eye Study.

Results

4944 of participants aged ≥ 30 y were included in this analysis. Participants with metabolic syndrome had a higher prevalence of CKD (20.9 % vs.15.8 % , P < 0.001) than those without. As the number of metabolic syndrome components increased, so did the prevalence of CKD (P < 0.001). The multivariate-adjusted odds ratio (OR) of chronic kidney disease in participants with metabolic syndrome was 1.293 (95 % CI 1.093–1.529) compared with those without. In multivariate logistic regression analysis, high blood pressure (OR 1.348; 95 % CI 1.122–1.619) and high fasting glucose (OR 1.501; 95 % CI 1.235–1.794) were independently associated with the risk for CKD. Compared with participants without any component, multivariate adjusted OR for CKD was 1.316 (95 % CI 1.004–1.723), 1.397(95 % CI 1.038–1.882), 1.672 (95 % CI 1.183–2.363) for those with 2, 3, 4 or 5 components, respectively.

Conclusion

In this rural Chinese population aged ≥ 30 y, metabolic syndrome was associated with CKD.