MicroRNAs as key mediators of hepatic detoxification
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- 作者：Yemiao Chen ; PhD ; chenyemiao@tmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author (Associate Research Fellow) ; Jingfang Xiao ; Xinli Zhang ; Xiuwu Bian ; PhD ; bianxiuwu@263.net" class="auth_mail" title="E-mail the corresponding author (Professor Director Institute of Pathology)
- 关键词：CYP ; cytochrome p450 ; UGTs ; UDP glycosyltransferases ; GSTs ; glutathione-S-transferases ; SULTs ; sulfotransferases ; OATs ; organic anion transporters ; MRPs ; multidrug-resistance proteins ; DGCR8 ; DiGeorge Syndrome Critical Region Gene 8 ; RISC ; RNA-induced silencing complex ; DDT ; 2 ; 2-dichlorodiphenyl-1 ; 1 ; 1-trichloroethane ; BP ; benzo[a]pyrene ; MC ; 3-methylcholanthrene ; TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzodioxin ; EROD ; ethoxyresorufin ; PROD ; pentoxyresorufin ; PXR ; pregnane X receptor ; AhR ; aryl hydrocarbon
- 刊名：Toxicology
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：368-369
- 期：Complete
- 页码：80-90
- 全文大小：1108 K
文摘
MicroRNAs (miRNAs) are a class of short noncoding RNAs that modulate gene expression at both transcriptional and post-transcriptional levels. Many studies have extensively revealed the significance of miRNAs in mediating liver development and diseases. However, their role in hepatic detoxification processes has been explored only recently. In this review, we summarized the up-to-date knowledge about miRNA dependent regulation of enzymes involved in all three phases of the drugs and xenobiotics detoxification process. We also discussed the role of miRNA in regulating some upstream nuclear receptors involving gene expression of enzymes for detoxification process in liver. The toxicological significance of miRNAs in liver diseases and future research perspectives are finally presented.