HU-induced polymorphous filamentation in fish pathogen Edwardsiella tarda leading to reduced invasion and virulence in zebrafish
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- 作者：Limei Wang ; Jingfan Xiao ; jfxiao@ecust.edu.cn" class="auth_mail ; cbema307@163.com" class="auth_mail ; Shilei Cui ; Qiyao Wang ; Haizhen Wu ; Qin Liu ; Yuanxing Zhang
- 关键词：Edwardsiella tarda ; Nucleoid-associated protein ; Filamentation ; Virulence
- 刊名：Veterinary Microbiology
- 出版年：25 June 2014
- 年：2014
- 卷：171
- 期：1-2
- 页码：165-174
- 全文大小：1760 K
文摘
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螖hupA mutant was found to be defective in cell growth, H2S production, and acid adaptation in log phase cultures.
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螖hupA mutant up-regulated the transcription levels of recA and sulA, resulting in filamentous morphology.
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螖hupA mutant showed a striking defect in EPC cell invasion, and the adhesion and internalization rates were reduced to 25% and 27% of the wild-type in log phase cultures.
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螖hupA mutant reduced proliferation abilities in the muscle, liver and intestine of zebrafish.