Evaluation of poly(lactic-co-glycolic acid) and poly(dl-lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection

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• 作者：Stella E. Aniagyei^a ; ¹ ; Lee B. Sims^a ; ¹ ; Danial A. Malik^c ; ¹ ; Kevin M. Tyo^c ; ^e ; ¹ ; Keegan C. Curry^a ; ¹ ; Woihwan Kim^b ; ¹ ; Daniel A. Hodge^a ; ¹ ; Jinghua Duan^a ; ^e ; ¹ ; Jill M. Steinbach-Rankins^a ; ^c ; ^d ; ^e ; ^{jill.steinbach@louisville.edu}
• 关键词：Electrospun fibers ; Herpes simplex virus 2 (HSV-2) ; Sexually transmitted infections (STIs) ; Microbicide ; Antiviral ; Acyclovir ; Intravaginal ; Drug delivery systems
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：238-251
• 全文大小：1895 K
• 卷排序：72

文摘

PLGA and PLCL EFs exhibit sustained-delivery of ACV through one month. EFs exhibit high ACV encapsulation efficiency and in vitro biocompatibility. EFs serve as both physical and chemical barriers to HSV-2 infection. Potent in vitro efficacy is provided against HSV-2 infection for all formulations. HSV-2 protection is independent of administration times within one month.