Suppressed expression of miR-29a/c leads to the high levels of VEGF in the gastric tumor microenvironment.
miR-29a/c regulates VEGF expression by directly targeting the 3′UTR of VEGF mRNA.
Microvesicles could be used as the nano-particles to transport artificial miRNAs.
Microvesicle-packed miR-29a/c can be transported in vivo, suppressing angiogenesis in gastric cancer.