Based on the iMHB approach, a novel series of 2-phenyl-imidazo[1,2-a]pyridine analogues were designed and synthesized.
Compounds 1a, 3b, 3d were found to have excellent antiproliferative activities against HeLa cell.
These compounds showed good tubulin polymerization inhibition activities.
These studies provided a new class of antitubulin agents with the potential to be clinically developed for cancer treatment.