A facile one-pot synthesis of 3-unsubstituted-2,4-oxazolidinediones via in situ generation of carbamates from α-hydroxyesters using trichloroacetyl isocyanate
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- 作者：Yue H. Li ; Li Zhang ; Pei-San Tseng ; Yongliang Zhang ; Yu Jin ; Jingkang Shen ; Jian Jin
- 关键词：3-Unsubstituted-2 ; 4-oxazolidinedione ; Trichloroacetyl isocyanate ; α ; -Hydroxyester ; Carbamate
- 刊名：Tetrahedron Letters
- 出版年：2009
- 出版时间：18 February 2009
- 年：2009
- 卷：50
- 期：7
- 页码：790-792
- 全文大小：154 K
文摘
A convenient, high yield one-pot methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from α-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding α-hydroxyester and trichloroacetyl isocyanate, then converted to the desired 3-unsubstituted 2,4-oxazolidinedione via intramolecular ring closure. This method is amenable to scale-up and requires no chromatographic purification.