Therapeutic effect of Ginkgo biloba polysaccharide in rats with focal cerebral ischemia/reperfusion (I/R) injury
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- 作者：Yongmei Yang ; Peifang Liu ; Lixia Chen ; Zhaojun Liu ; Huixue Zhang ; Jianjian Wang ; Xuesong Sun ; Weiqi Zhong ; Na Wang ; Kuo Tian ; Jingshun Zhao
- 关键词：Ginkgo biloba L. ; Polysaccharide ; Purification ; Cerebral ischemia/reperfusional ; Neuroprotection
- 刊名：Carbohydrate Polymers
- 出版年：2013
- 出版时间：6 November, 2013
- 年：2013
- 卷：98
- 期：2
- 页码：1383-1388
- 全文大小：549 K
文摘
An araban type polysaccharide (GBPw) was purified from the leaves of Ginkgo biloba. The present study aimed to investigate the protective effects of GBPw on focal ischemia/reperfusion (I/R) injury in rat brain. The results of this study demonstrated that GBPw had a positive effect on the rat brain when administered 7 days before focal cerebral I/R injury. This effect was evident with the improvements in neurological deficits, reduction in infarct volume, MDA content and the levels of pro-inflammatory cytokines (TNF-¦Á and IL-1¦Â), and elevation in the SOD and MPO activities and the levels of anti-inflammatory cytokine (IL-10). Thus, the beneficial effects of GBPw on cerebral I/R injury may result from the reduction of oxidative stress and the inhibition of NO production and inflammation induced by I/R. The neuroprotective effects of GBPw supplement may have potential implication in the future for prevention/protection against cerebral ischemic stroke.