Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy
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- 作者：Jerome Clasadontea ; 1 ; Lydie Morela ; 1 ; Camila M. Barrios-Camachoa ; b ; Ming Sum R. Chianga ; Jinhua Zhangc ; Lakshmanan Iyera ; Philip G. Haydona ; b ; Yongjie Yanga ; b ; yongjie.yang@tufts.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Astroglia ; Epilepsy ; Gene profiling
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：315-325
- 全文大小：1877 K
文摘
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Pilocarpine injections induce status epilepticus (SE) and spontaneous recurrent seizures (SRSs) in BAC aldh1l1 TRAP mice.
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TRAP approach-dependent profiling of hippocampal or cortical astrocyte mRNAs during seizure development.
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Molecular changes in hippocampal astrocytes during latent phase provide important pathways for the development of SRSs.
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Cortical astrocytes show a gradual delayed expression changes during epileptogenesis.