Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system
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- 作者：Seung-Soo Han ; Jinjoo Lee ; Yideul Jung ; Myeong-Ho Kang ; Jung-Hyub Hong ; Min-Suk Cha ; Yu-Jin Park ; Ezra Lee ; Cheol-Hee Yoon1 ; Yong-Soo Bae ; ysbae04@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Poliovirus Sabin 1 vector ; RPS-CTP CTL vector ; HIV-1 p24 ; Recombinant poliovirus ; p24-specific CTL ; Oral CTL vaccine
- 刊名：Vaccine
- 出版年：2015
- 出版时间：11 September 2015
- 年：2015
- 卷：33
- 期：38
- 页码：4827-4836
- 全文大小：2178 K
文摘
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Poliovirus Sabin1-derived CTL vaccine vector RPS-CTP is proposed.
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RPS-CTP vector contains cytoplasmic transduction peptide (CTP).
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HIV-1 p24-expressing recombinant poliovirus (rec-PV) was produced.
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Rec-PV efficiently induced p24-specific CTL in PVR-Tg mice vaccinated orally.
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Vaccinated mice were resistant to challenge with p24-expressing vaccinia virus.