Tirofiban induces vasorelaxation of the coronary artery via an endothelium-dependent NO-cGMP signaling by activating the PI3K/Akt/eNOS pathway
详细信息 查看全文
- 作者：Tianyang Xiaa ; b ; 1 ; Weiwei Guana ; b ; 1 ; Jinjuan Fua ; b ; Xue Zoua ; b ; Yu Hana ; b ; Caiyu Chena ; b ; Lin Zhoua ; b ; Chunyu Zenga ; b ; chunyuzeng01@163.com" class="auth_mail" title="E-mail the corresponding author ; Wei Eric Wanga ; b ; weiericwang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tirofiban ; Vasorelaxation ; Coronary artery ; No-reflow ; PI3K/Akt/eNOS
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：3 June 2016
- 年：2016
- 卷：474
- 期：3
- 页码：599-605
- 全文大小：884 K
文摘
- listitem" id="list_ulist0010">
- •
Tirofiban induces vasorelaxation in isolated rat coronary artery.
- •
The tirofian increased the expression of eNOS phosphorylation in HUVECs.
- •
Tirofiban induces vasorelaxation via NO-cGMP signaling activated by PI3K/Akt/eNOS.
- •
Tirofiban-induced vasorelaxation is associated with BKCa channel.