Effects of sodium fluoride on MAPKs signaling pathway in the gills of a freshwater teleost, Cyprinus carpio
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- 作者：Jinling Caoa ; caojinling7928@yahoo.com.cn" class="auth_mail ; Jianjie Chena ; Jundong Wanga ; wangjd@sxau.edu.cn" class="auth_mail ; Paul Klerksb ; Lingtian Xiec ; xielt@iae.ac.cn" class="auth_mail
- 关键词：Fluoride ; MAPKs signaling pathway ; Cyprinus carpio ; Gill ; Western blotting
- 刊名：Aquatic Toxicology
- 出版年：July 2014
- 年：2014
- 卷：152
- 期：Complete
- 页码：164-172
- 全文大小：1178 K
文摘
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ERK relative activation decreased and JNK activation increased as fluoride level.
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MAPKs inhibitors effectively prevented JNK induction and ERK inhibition.
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Activation of JNK and inactivation of ERK were caused by oxidative stress.
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JNK activation and ERK inactivation mechanism play a role in gill damage by fluoride.