Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy

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• 作者：Jinping Wang^a ; Fang Guo^a ; Meng Yu^a ; Li Liu^a ; Fengping Tan^a ; Ran Yan^b ; ^{ran.yan@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Nan Li^a ; ^{linan19850115@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Rapamycin ; Lipid-polyaniline nanoparticles ; Enhanced photothermal therapy ; Antiangiogenesis ; Imaging-guided therapy
• 刊名：Journal of Controlled Release
• 出版年：2016
• 出版时间：10 September 2016
• 年：2016
• 卷：237
• 期：Complete
• 页码：23-34
• 全文大小：2573 K

文摘

Imaging-guided photothermal therapy (PTT) has promising application for treating tumors. Nevertheless, so far imaging-guided photothermal drug-delivery systems have been developed with limited success for tumor chemo-photothermal therapy. In this study, as the proof-of-concept, a stimuli-responsive tumor-targeting rapamycin/DiR loaded lipid-polyaniline nanoparticle (RDLPNP) for dual-modal imaging-guided enhanced PTT efficacy is reported for the first time. In this system, polyaniline (PANI) with π-π electronic conjugated system and effective photothermal efficiency is chosen as the appropriate model receptor of fluorescence resonance energy transfer (FRET), and loaded cyanine probe (e.g., 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide, DiR) acts as the donor of near-infrared fluorescence (NIRF). In addition, rapamycin (RAPA), which is used as the antiangiogenesis chemotherapeutic drug, can cutdown the tumor vessels and delay tumor growth obviously. After intravenous treatment of RDLPNPs into Hela tumor bearing mice, fluorescent (from DiR) and enhanced photoacoustic (from DLPNPs) signals were found in tumor site over time, which reached to peak at the 6 h time point. After irradiating with an NIR laser, a good anti-tumor effect was observed owing to the enhanced photothermal and antiangiogenic effect of RDLPNPs. These results show that the multifunctional nanoparticle can be used as a promising imaging-guided photothermal drug delivery nanoplatform for cancer therapy.