Visfatin stimulates endometrial cancer cell proliferation via activation of PI3K/Akt and MAPK/ERK1/2 signalling pathways
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- 作者：Yingmei Wang1 ; Chao Gao1 ; Yanfang Zhang ; Jinping Gao ; Fei Teng ; Wenyan Tian ; Wen Yang ; Ye Yan ; Fengxia Xue ; fengxiaxue1962@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endometrial carcinoma ; Visfatin ; Ishikawa cells ; KLE cells ; PI3K/AKT pathway ; MAPK/ERK1/2 pathway
- 刊名：Gynecologic Oncology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：143
- 期：1
- 页码：168-178
- 全文大小：1875 K
文摘
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Effects of visfatin on endometrial carcinoma progression were examined.
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Visfatin stimulated proliferation and inhibited apoptosis of both Ishikawa and KLE cells.
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Visfatin promoted Ishikawa xenograft growth in vivo, exhibiting with stronger proliferation index (Ki-67) expression.
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Visfatin effects were abrogated by inhibiting PI3K (LY294002) and MEK (U0126).
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Visfatin promotes endometrial cancer progression via PI3K/Akt and MAPK/ERK signalling.