MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation
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- 作者：Yuan Tan1 ; Bodour AlKhamees1 ; Deyong Jia1 ; Li Li1 ; Jean-Franç ; ois Couture1 ; 2 ; Daniel Figeys1 ; 2 ; Masahisa Jinushi3 ; jinushi@z7.keio.jp" class="auth_mail" title="E-mail the corresponding author ; Lisheng Wang1 ; 2 ; 4 ; lwang@uottawa.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：5
- 期：5
- 页码：741-752
- 全文大小：4883 K
文摘
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MFG-E8 is enriched in undifferentiated but diminished in differentiated ESCs
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MFG-E8 promotes allogeneic engraftment of ESC-derived tissues across the MHC barrier
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ESC-produced MFG-E8 inhibits Th1/Th2/Th17 while promoting regulatory T cells
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MFG-E8 modulates T cell polarization via inhibiting PKCθ phosphorylation