DDPH inhibits CYP2D1 and CYP3A1 activity, mRNA and protein expression in rats.
DDPH is a potential dual inhibitor of hepatic CYP2D and CYP3A in rats and humans.
DDPH affects the pharmacokinetics of propafenone, leading to an increase of AUC.
Caution is required when DDPH is co-administered with CYP2D or CYP3A substrates.