Expression of recombinant human α-lactalbumin in milk of transgenic cloned pigs is sufficient to enhance intestinal growth and weight gain of suckling piglets
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- 作者：Jin Maa ; 1 ; Qiuyan Lia ; 1 ; Yan Lib ; Xiao Wenb ; Zhiyuan Lib ; Zaihu Zhangc ; Jiuming Zhangc ; Zhengquan Yua ; Ning Lia ; ninglcau@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-LA ; α-lactalbumin ; HLA ; human α-lactalbumin ; rHLA ; recombinant human α-lactalbumin ; rHLF ; recombinant human lactoferrin ; GLP-2 ; glucagon-like peptide 2 ; DPP-IV ; diepeptidyl peptidase-IV ; BAC ; bacterial artificial chromosome ; PAGE ; poly-acrylamide gel electrophoresis ; pH ; hydrogen ion concentration ; OD ; optical density
- 刊名：Gene
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：584
- 期：1
- 页码：7-16
- 全文大小：1019 K
文摘
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The expression level of rHLA in transgenic cloned sows was high and stable during the lactation.
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The rHLA can inhibit the enzyme activity of dipeptidyl peptidase-IV in vitro and in vivo.
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The piglets reared by transgenic sows showed better performance in gain of body weight and intestine growth than the control piglets.