Investigation of cell adhesion in chitosan membranes for peripheral nerve regeneration

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• 作者：Cristiana R. Carvalho^a ; ^b ; Rita Ló ; pez-Cebral^a ; ^b ; Joana Silva-Correia^a ; ^b ; Joana M. Silva^a ; ^b ; Joã ; o F. Mano^a ; ^b ; Tiago H. Silva^a ; ^b ; Thomas Freier^c ; Rui L. Reis^a ; ^b ; Joaquim M. Oliveira^a ; ^b ; ¹ ; ^{miguel.oliveira@dep.uminho.pt}
• 关键词：Peripheral nerve injuries ; Biomaterials ; Chitosan ; Degree of acetylation ; Schwann cells ; L929 mouse fibroblast cells
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：1122-1134
• 全文大小：1835 K
• 卷排序：71

文摘

Three chitosan membranes were produced with very specific degrees of acetylation (DA I: 1%, DA II: 2%, DA III: 5%). Physicochemical characterization of the membranes showed their suitability for peripheral nerve regeneration purposes. In vitro cellular tests confirmed the potential of the membranes as peripheral nerve regeneration systems. The results indicated that DA III membrane should be the one considered for further peripheral nerve regeneration studies.