GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling
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- 作者：Barbara D'Angeloa ; C. Joakim Eka ; Yanyan Sunb ; Changlian Zhub ; Mats Sandbergc ; Carina Mallarda ; carina.mallard@neuro.gu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Perinatal ; Hypoxia-ischaemia ; GSK3β ; STAT3 ; Neuroinflammation ; Oxidative stress
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：13-23
- 全文大小：1639 K
文摘
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Cerebral hypoxia-ischaemia (HI) induced activation of GSK3β in the neonatal brain.
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Selective inhibition of GSK3β was neuroprotective in neonatal brain injury.
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HI induced activation and nuclear translocation of STAT3 in glial cells.
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GSK3β inhibition reduced oxidative/inflammatory responses via STAT3 downregulation.