An ABC-type transporter was found in sequenced isolates with increased narasin MIC.
The transporter was not found in sequenced isolates without increased narasin MIC.
A similar transporter confers resistance to tetronasin, another polyether ionophore.
Presence of the ABC-type transporter was correlated to narasin MIC ≥2 mg/L.
This is the first report of transferrable genes giving increased narasin MIC.