[18F]Haloperidol Binding in Baboon Brain in Vivo
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- 作者：Yousef ; Khalil A. ; Fowler ; Joanna S. ; Volkow ; Nora D. ; Dewey ; Stephen L. ; Shea ; Colleen ; Schlyer ; David J. ; et. al.
- 关键词：[18F]haloperidol ; PET ; Sigma binding sites ; Dopamine D2 receptors
- 刊名：Nuclear Medicine and Biology
- 出版年：1996
- 出版时间：January, 1996
- 年：1996
- 卷：23
- 期：1
- 页码：47-52
- 全文大小：690 K
文摘
The binding of [18F]haloperidol to dopamine D2 and to sigma recognition sites in baboon brain was examined using positron emission tomography (PET). Studies were performed at baseline and after treatment with either haloperidol (to evaluate saturability), (+)-butaclamol (which has specificity for dopamine D2 receptors) or (−)-butaclamol (which has specificity for sigma sites). Binding was widespread. Treatment with (−)-butaclamol had no effect, whereas (+)-butaclamol selectively reduced the uptake in striatum. Haloperidol increased the clearance rate from all brain regions. These results indicate that the binding profile of [18F]haloperidol does not permit the selective examination of either dopamine D2 or sigma sites using PET.