Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity
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- 作者：Blanka Kucejova1 ; Joao Duarte1 ; Santhosh Satapati1 ; Xiaorong Fu1 ; Olga Ilkayeva5 ; Christopher B. Newgard5 ; James Brugarolas3 ; 4 ; Shawn C. Burgess1 ; 2 ; shawn.burgess@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：16
- 期：2
- 页码：508-519
- 全文大小：2977 K
文摘
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Loss of the hepatic insulin receptor (IR) stimulates oxidative metabolism in liver
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Activation of mTORC1 suppresses oxidative metabolism in liver
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Simultaneous IR loss and mTORC1 activation cause hyperglycemia and impaired ketosis