CD301b+ Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha
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- 作者：Yosuke Kumamoto1 ; Joao Paulo G. Camporez2 ; Michael J. Jurczak2 ; Marya Shanabrough3 ; Tamas Horvath3 ; Gerald I. Shulman2 ; 4 ; Akiko Iwasaki1 ; 4 ; 5 ; akiko.iwasaki@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：alternatively activated macrophage ; glucose metabolism ; adipose tissue macrophage
- 刊名：Immunity
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：45
- 期：3
- 页码：583-596
- 全文大小：7336 K
文摘
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In vivo depletion of CD301b+ MNPs results in reduced food intake and weight loss
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Depletion of CD301b+ MNPs reduces blood glucose and increases insulin sensitivity
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CD301b+ MNP-depleted mice have decreased serum RELMα concentration
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Reconstitution of RELMα restores body weight and normoglycemia