Microcarrier-based platforms for in vitro expansion and differentiation of human pluripotent stem cells in bioreactor culture systems
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- 作者：Sara M. Badenes ; Tiago G. Fernandes ; Carlos A.V. Rodrigues ; Maria Margarida Diogo ; Joaquim M.S. Cabral<sup> ; sup><sup>joaquim.cabral@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Human pluripotent stem cells (hPSC) ; hPSC derivatives ; Microcarriers ; Bioreactors ; Large-scale production ; Integrated expansion and differentiation
- 刊名：Journal of Biotechnology
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：234
- 期：Complete
- 页码：71-82
- 全文大小：962 K
文摘
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Microcarrier-based culture systems achievements for hPSC manufacturing are reviewed.
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Crucial aspects that influence the performance of these systems are discussed.
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Integrated platforms for hPSC expansion and directed differentiation are evaluated.
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Recent progress includes addressing GMP-compliant microcarriers-based systems.