Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis
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- 作者：Arturo Cardenas-Blancoa ; Arturo.Cardenas@dzne.de" class="auth_mail" title="E-mail the corresponding author ; Judith Machtsa ; Judith.Machts@dzne.de" class="auth_mail" title="E-mail the corresponding author ; Julio Acosta-Cabroneroa ; Julio.Acosta@dzne.de" class="auth_mail" title="E-mail the corresponding author ; Joern Kaufmannb ; jkauf@neuro2.med.uni-magdeburg.de" class="auth_mail" title="E-mail the corresponding author ; Susanne Abdullaa ; b ; c ; susanne.abdulla@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Katja Kollewec ; Kollewe.Katja@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Susanne Petric ; Petri.Susanne@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Stefanie Schreibera ; b ; stefanie.schreiber@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Hans-Jochen Heinzea ; b ; d ; Hans-Jochen.Heinze@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Reinhard Denglerc ; Dengler.Reinhard@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Stefan Vielhabera ; b ; Stefan.Vielhaber@dzne.de" class="auth_mail" title="E-mail the corresponding author ; Peter J. Nestora ; Peter.Nestor@dzne.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Longitudinal ; Diffusion ; MRI ; ALSFRS-R ; ALS ; Biomarker
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：11
- 期：Complete
- 页码：408-414
- 全文大小：633 K
文摘
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Three time points were used for the first time to assess imaging biomarkers in ALS.
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Fractional anisotropy of the corticospinal tract showed linear decline.
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No atrophy measure was useful to track change.
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The ALSFRS-R clinical scale remains more sensitive than imaging biomarkers.