Variation in dermatologist beliefs about the safety and effectiveness of treatments for moderate to severe psoriasis

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• 作者：Katrina Abuabara ; MD ; MA^a ; Joy Wan ; MD^a ; Andrea B. Troxel ; ScD^b ; ^c ; Daniel B. Shin ; MS^a ; ^c ; Abby S. Van Voorhees ; MD^a ; Bruce F. Bebo Jr. ; PhD^d ; Gerald G. Krueger ; MD^e ; Kristina Callis Duffin ; MD^e ; Joel M. Gelfand ; MD ; MSCE^a ; ^b ; ^c ; ^{Joel.Gelfand@uphs.upenn.edu}
• 关键词：biologics ; comparative effectiveness ; pharmacoepidemiology ; phototherapy ; psoriasis ; systemic therapies
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：68
• 期：2
• 页码：262-269
• 全文大小：123 K

文摘

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Background

Multiple systemic treatments are available for moderate to severe psoriasis, but dermatologists' perceptions of these treatments are unknown. Physician perceptions can influence prescribing patterns and patient outcomes, and may help to explain variations in clinical practice.

Objective

We sought to describe the variation in dermatologist's beliefs about the safety and effectiveness of psoriasis treatments and evaluate how these relate to dermatologist characteristics and treatment preferences.

Methods

We conducted a cross-sectional mail survey of a random sample of 500 National Psoriasis Foundation (NPF) members and 500 American Academy of Dermatology (AAD) members who treat psoriasis.

Results

Of 989 clinicians who could be contacted, 246 NPF members and 141 AAD members returned the survey (39 % response rate). Respondents perceived infliximab, ustekinumab, cyclosporine, and adalimumab to have the highest likelihood of skin clearance in 3 months (67 % -75 % ). Etanercept, adalimumab, ultraviolet B, and ustekinumab had the lowest perceived likelihood of side effects requiring treatment discontinuation (9 % -11 % ). Up to 49 % of respondents ¡°didn't know¡± the effectiveness or likelihood of side effects; calculated coefficients of variation were higher for perceived likelihood of side effects than perceived effectiveness. There were few significant associations between safety and effectiveness perceptions and respondent characteristics, and treatment preferences were not consistently predictive of perceptions.

Limitations

Only dermatologists with interest in treating psoriasis were surveyed and general perceptions were elicited via survey format. Perceptions may differ between survey respondents and nonrespondents.

Conclusions

Psoriasis providers demonstrate wide variation in their perception of the effectiveness and especially safety of systemic treatments.