p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation

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• 作者：Hanbing He¹ ; ³ ; Cheng Wang¹ ; ³ ; Qian Dai² ; Fengtian Li¹ ; Johann Bergholz¹ ; Zhonghan Li¹ ; Qintong Li² ; ^{liqintong@scu.edu.cn} ; Zhi-Xiong Xiao¹ ; ^{jimzx@scu.edu.cn}
• 关键词：mouse embryonic stem cells ; p53 ; p73 ; RB ; DNA damage ; G2/M arrest ; apoptosis ; differentiation ; doxorubicin ; naive and primed state
• 刊名：Stem Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：7
• 期：6
• 页码：1087-1098
• 全文大小：3064 K
• 卷排序：7

文摘

p53/p73 are key for DNA damage-induced apoptosis but not G2/M arrest in mESCs Both p53 and p73 are required for differentiation-induced apoptosis in mESCs Doxorubicin induces RB via p53-mediated suppression of miR-17-92 and miR-106a-363 p73 expression is induced upon differentiation in mESCs