- 作者：Jacques Donnez ; M.D. ; Ph.D.a ; jacques.donnez@uclouvain.be ; Pascale Jadoul ; M.D.a ; Cé ; line Pirard ; M.D. ; Ph.D.a ; Graham Hutchings ; M.D. ; Ph.D.b ; Dominique Demylle ; Ph.D.a ; Jean Squifflet ; M.D. ; Ph.D.a ; Johan Smitz ; M.D. ; Ph.D.c ; Marie-Madeleine Dolmans ; M.D. ; Ph.D.a
- 关键词：Bilateral oophorectomy ; ovarian cortex ; cryopreservation ; transplantation ; fertility restoration
- 刊名：Fertility and Sterility
- 出版年：2012
- 出版时间：September, 2012
- 年：2012
- 卷：98
- 期：3
- 页码：720-725
- 全文大小：632 K
Objective
To report the restoration of ovarian function and pregnancy in a woman after bilateral oophorectomy for benign disease after autotransplantation of cryopreserved ovarian cortex.Design
Case report.
Setting
Gynecology research unit in a university hospital.
Patient(s)
A 28-year-old woman who underwent bilateral adnexectomy for ovarian abscesses at the age of 18 years.
Intervention(s)
We performed ovarian cortex autotransplantation to a peritoneal pocket in the broad ligament.
Main Outcome Measure(s)
Restoration of ovarian activity and pregnancy.
Result(s)
Restoration of ovarian function began at 20 weeks and was achieved 24 weeks after transplantation. After the fifth stimulation attempt, two mature oocytes were obtained and microinjected. One embryo (seven cells) was obtained and transferred, leading to a normal pregnancy. The patient delivered a healthy baby boy weighing 2,370 g at 38 weeks of gestation.
Conclusion(s)
Ovarian cortex cryopreservation can be performed at the time of surgery for benign diseases when fertility is impaired. We report the first pregnancy to occur after ovarian tissue cryopreservation for benign ovarian pathology after bilateral oophorectomy.