17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content
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- 作者：Albert Ambergera ; Albert.Amberger@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Andrea J. Deutschmanna ; Pia Traunfellnera ; Patrizia Moserb ; René ; G. Feichtingerc ; Barbara Koflerc ; Johannes Zschockea ; Johannes.Zschocke@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colorectal cancer ; Mitochondrial DNA ; Survival ; 17β-Hydroxysteroid dehydrogenase type 10 ; Prognostic marker
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 April 2016
- 年：2016
- 卷：374
- 期：1
- 页码：149-155
- 全文大小：1350 K
文摘
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We examined expression of HSD10 in colorectal cancer.
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HSD10 is an independent prognostic marker for survival.
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HSD10 expression correlates with mitochondrial DNA content in cancer.
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Decreased HSD10 expression causes mitochondrial DNA depletion in cancer cells.