Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine

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• 作者：U. Sailaja^a ; ^{sailajaurpayil@gmail.com} ; M. Shahin Thayyil^b ; N.S. Krishna Kumar^c ; G. Govindaraj^c ; K.L. Ngai^d
• 关键词：Broadband dielectric spectroscopy ; Dielectric relaxation strength ; Glass transition ; Nizatidine ; Perphenazine
• 刊名：European Journal of Pharmaceutical Sciences
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：147-151
• 全文大小：1066 K
• 卷排序：99

文摘

The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.