Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum
详细信息 查看全文
- 作者：Ilan Gobius1 ; ilan.gobius@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Laura Morcom1 ; Rodrigo Suá ; rez1 ; Jens Bunt1 ; Polina Bukshpun3 ; William Reardon4 ; William B. Dobyns5 ; 6 ; John L.R. Rubenstein7 ; A. James Barkovich8 ; Elliott H. Sherr3 ; Linda J. Richards1 ; 2 ; 9 ; richards@uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：astrocyte ; callosal agenesis ; interhemispheric fissure ; Fgf8 ; Nfia ; Nfib
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：735-747
- 全文大小：7888 K
文摘
- •
Developmental remodeling of the midline is required for callosal tract formation
- •
Maturation and intercalation of astroglia mediate interhemispheric remodeling
- •
Fgf8-Nfi signaling regulates astroglial-mediated interhemispheric remodeling
- •
Interhemispheric remodeling defects underlie congenital callosal agenesis in humans