CD8⁺ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections

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• 作者：Bing He¹ ; ² ; ¹⁰ ; Shaojun Xing³ ; ¹⁰ ; Changya Chen⁵ ; Peng Gao¹ ; ² ; Li Teng⁸ ; Qiang Shan³ ; Jodi A. Gullicksrud³ ; ⁶ ; Matthew D. Martin⁴ ; ⁶ ; Shuyang Yu⁹ ; John T. Harty³ ; ⁶ ; Vladimir P. Badovinac⁴ ; ⁶ ; Kai Tan¹ ; ² ; ⁷ ; ^{tank1@email.chop.edu} ; Hai-Hui Xue³ ; ⁶ ; ⁷ ; ^{hai-hui-xue@uiowa.edu}
• 关键词：Enhancers ; Super enhancers ; Naï ; ve CD8 T cells ; Effector CD8 T cells ; Central memory ; CD8 T cells ; Epigenetics ; Transcriptional regulatory network ; Enhancer-promoter interactome ; Hi-C
• 刊名：Immunity
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：45
• 期：6
• 页码：1341-1354
• 全文大小：3623 K
• 卷排序：45

文摘

Comprehensive epigenomic mapping in naive, effector, and memory CD8+ T cells Enhancers and super enhancers are dynamically regulated during CD8+ T cell responses Re-wiring of regulatory circuitry mediated by dynamic enhancer-promoter interactome Network analysis identifies novel regulators during CD8+ T cell response stages