Olfactory impairment predicts cognitive decline in early Parkinson's disease
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- 作者：Michelle E. Fullarda ; b ; 1 ; michelle.fullard@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Baochan Tranb ; 1 ; Baochan.Tran@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Sharon X. Xiec ; sxie@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Jon B. Toledob ; d ; jtoledo@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Christi Scordiab ; Christi.Scordia@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Carly Linderb ; Carly.Linder@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Rachael Purrib ; Rachael.Purri@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Daniel Weintrauba ; b ; e ; Daniel.Weintraub@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; John E. Dudaa ; b ; john.duda@med.va.gov" class="auth_mail" title="E-mail the corresponding author ; Lama M. Chahineb ; 1 ; Lama.chahine@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; James F. Morleya ; b ; 1 ; James.Morley@uphs.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; Olfaction ; Mild cognitive impairment ; Non-motor symptoms ; Cerebrospinal fluid
- 刊名：Parkinsonism & Related Disorders
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：25
- 期：Complete
- 页码：45-51
- 全文大小：616 K
文摘
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Olfactory impairment is common in Parkinson's disease.
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Lower UPSIT score was associated with more severe non-motor symptoms.
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Worse olfaction was associated with a greater decline in MoCA score.
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Addition of AD CSF biomarkers to olfaction may improve ability to predict MCI.