Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair
详细信息 查看全文
- 作者：Bruno Vaz1 ; 7 ; Marta Popovic1 ; 7 ; Joseph A. Newman2 ; John Fielden1 ; Hazel Aitkenhead2 ; Swagata Halder1 ; Abhay Narayan Singh1 ; Iolanda Vendrell1 ; 3 ; Roman Fischer3 ; Ignacio Torrecilla1 ; Neele Drobnitzky1 ; Raimundo Freire4 ; David J. Amor5 ; 6 ; Paul J. Lockhart5 ; 6 ; Benedikt M. Kessler3 ; Gillies W. McKenna1 ; Opher Gileadi2 ; Kristijan Ramadan1 ; 8 ; kristijan.ramadan@oncology.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：SPARTAN/DVC1 ; DNA-dependent metalloprotease ; DNA-protein crosslink repair ; DNA replication ; Ruijs-Aalfs/SPARTAN syndrome ; cancer ; aging
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：64
- 期：4
- 页码：704-719
- 全文大小：5526 K
文摘
- •
DNA-protein crosslinks (DPCs) stall DNA replication and induce genomic instability
- •
SPARTAN (SPRTN) is a DNA replication-coupled metalloprotease which proteolyses DPCs
- •
SPRTN metalloprotease is a fundamental enzyme in DPC repair pathway
- •
Ruijs-Aalfs syndrome is caused by a defect in DPC repair due to mutations in SPRTN