General intelligence is associated with subclinical inflammation in Nepalese children: A population-based plasma proteomics study
详细信息 查看全文
- 作者：Sun Eun Leea ; slee278@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; Keith P. West Jr.a ; kwest1@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; Robert N. Coleb ; rcole@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Kerry J. Schulzea ; kschulz1@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; Lee Shu-Fune Wua ; lwu2@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; James D. Yagerc ; jyager1@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; John Groopmanc ; jgroopm1@jhu.edu" class="auth_mail" title="E-mail the corresponding author ; Parul Christiana ; pchrist1@jhu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intelligence ; Universal Nonverbal Intelligence Test ; Plasma proteomics ; Mass spectrometry ; Inflammation ; Children ; Nepal ; Cohort study
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：253-263
- 全文大小：518 K
文摘
- •
Quantitative proteomics was applied to identify plasma proteins associated with child cognition.
- •
Nutritional status sensitive proteins were associated with increased intelligence test scores.
- •
Inflammatory proteins were associated with decreased test scores, independent of risk factors.
- •
A protein regulating glycolysis contributed to the variability in the test scores.
- •
Plasma proteomics can provide candidate proteins that reflect biological associations with child cognition.