Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis
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- 作者：Vikram Saini1 ; 2 ; 7 ; Bridgette M. Cumming5 ; 7 ; Loni Guidry1 ; Dirk A. Lamprecht5 ; John H. Adamson5 ; Vineel P. Reddy1 ; Krishna C. Chinta1 ; James H. Mazorodze5 ; Joel N. Glasgow1 ; Melissa Richard-Greenblatt3 ; Anaximandro Gomez-Velasco3 ; Horacio Bach3 ; Yossef Av-Gay3 ; Hyungjin Eoh4 ; Kyu Rhee4 ; Adrie J.C. Steyn1 ; 2 ; 5 ; 6 ; asteyn@uab.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：14
- 期：3
- 页码：572-585
- 全文大小：3383 K
文摘
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WhiB3 regulates EGT production and maintains bioenergetic homeostasis in Mtb
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EGT modulates drug sensitivity and protects Mtb from diverse oxidative stressors
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EGT is essential for Mtb survival in macrophages and in mice