Factors associated with improved toxicity and tolerability of intraperitoneal chemotherapy in advanced-stage epithelial ovarian cancers

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• 作者：Patrick Teefey ; MD^a ; Nadim Bou Zgheib ; MD^a ; ^b ; Sachin M. Apte ; MD^b ; Jesus Gonzalez-Bosquet ; MD ; PhD^b ; Patricia L. Judson ; MD^b ; William S. Roberts ; MD^b ; Johnathan M. Lancaster ; MD ; PhD^b ; Robert M. Wenham ; MD^b
• 关键词：intraperitoneal chemotherapy ; ovarian cancer ; toxicity
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：208
• 期：6
• 页码：501.e1-501.e7
• 全文大小：759 K

文摘

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Objective

We sought to evaluate the toxicity and tolerability of the intraperitoneal/intravenous regimen by comparing the modified regimen that is used at the Moffitt Cancer Center vs the published findings of the Gynecologic Oncology Group Study 172.

Study Design

Using the Moffitt database, we evaluated the outcomes of patients who underwent primary optimal cytoreduction for stage IIC-IV epithelial ovarian, tubal, and peritoneal carcinoma followed by the intent-to-treat with intraperitoneal/intravenous chemotherapy. National Cancer Institute Common Terminology Criteria for Adverse Events (version 3.0) was used to grade adverse events.

Results

We analyzed patient data from 2006-2011 and identified 69 patients who met our inclusion criteria. The most frequent grade 3/4 toxicities were neutropenia (48 % ), gastrointestinal (9 % ), metabolic (9 % ), and infection (5 % ). Remaining toxicities occurred in <5 % of patients. Patients received a greater number of cycles compared with the Gynecologic Oncology Group Study 172 (4.28 vs 3.66, respectively; P = .0088).

Conclusion

With the use of supportive care and the preemptive management of established side-effects, the associated toxicities and tolerability of intraperitoneal chemotherapy can be improved.