This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (ong class="boldFont">4ong>) shows a similar minimum inhibitory concentration of 6.25 渭g/mL as compared to that of methicillin (3.125 渭g/mL) against Staphylococcus aureus.