Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling
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- 作者：Eunice Yuen Ting Lau1 ; 2 ; 6 ; Jessica Lo1 ; 2 ; 6 ; Bowie Yik Ling Cheng1 ; 2 ; Mark Kin Fai Ma1 ; 2 ; Joyce Man Fong Lee1 ; 2 ; Johnson Kai Yu Ng1 ; 3 ; Stella Chai1 ; 3 ; Chi Ho Lin4 ; Suk Ying Tsang5 ; Stephanie Ma1 ; 3 ; Irene Oi Lin Ng1 ; 2 ; iolng@hku.hk" class="auth_mail" title="E-mail the corresponding author ; Terence Kin Wah Lee1 ; 2 ; 6 ; terence.kw.lee@polyu.edu.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer-associated fibroblasts (CAFs) ; FRA1 ; HEY1 ; hepatocyte growth factor (HGF) ; tumor-initiating cells (T-ICs)
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：15
- 期：6
- 页码：1175-1189
- 全文大小：5468 K
文摘
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The presence of α-SMA(+) CAFs correlates with poor prognosis of HCC
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CAFs regulate liver T-ICs through paracrine secretion of HGF
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FRA1 is required for HGF/c-Met-mediated T-IC phenotypes
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The HGF-mediated c-Met/FRA1/HEY1 cascade represents a therapeutic target for HCC