Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
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- 作者：Melissa V. Gammons1 ; 2 ; melissag@mrc-lmb.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Miha Renko1 ; 2 ; Christopher M. Johnson1 ; Trevor J. Rutherford1 ; Mariann Bienz1 ; 3 ; mb2@mrc-lmb.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：64
- 期：1
- 页码：92-104
- 全文大小：4739 K
文摘
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Wnt signalosome assembly by Dishevelled depends on DEP-dependent dimerization
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DEP dimerization via domain swapping favors unidirectional signaling
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DEP-dependent cross-linking of Dishevelled polymers triggers phase transition
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DEP dimerization is mutually exclusive with DEP-dependent binding to Frizzled