Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair
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- 作者：Sibel Naska1 ; 7 ; 8 ; Scott A. Yuzwa1 ; 7 ; Adam P.W. Johnston1 ; Smitha Paul1 ; Kristen M. Smith1 ; 9 ; Maryline Paris1 ; 10 ; Michael V. Sefton6 ; Alessandro Datti2 ; 3 ; Freda D. Miller1 ; 4 ; 5 ; fredam@sickkids.ca" class="auth_mail" title="E-mail the corresponding author ; David R. Kaplan1 ; 4 ; dkaplan@sickkids.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：6
- 期：1
- 页码：74-84
- 全文大小：3371 K
文摘
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Small-molecule screens identify compounds that enhance SKP self-renewal
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Alprostadil and trimebutine maleate both increase SKP self-renewal
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Both compounds likely act by promoting activation of the MEK-ERK pathway
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Both compounds activated dermal precursors in vivo to enhance wound healing