Multidrug-resistant oral Capnocytophaga gingivalis responsible for an acute exacerbation of chronic obstructive pulmonary disease: Case report and literature review

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• 作者：Elodie Ehrmann^a ; ^b ; Anne Jolivet-Gougeon^c ; ^d ; ^{anne.gougeon@univ-rennes1.fr} ; Martine Bonnaure-Mallet^c ; ^d ; Thierry Fosse^e ; ^f
• 关键词：Chronic obstructive pulmonary disease ; Capnocytophaga gingivalis ; Antibiotic resistance ; Oral microbiota ; Fluoroquinolone
• 刊名：Anaerobe
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：42
• 期：Complete
• 页码：50-54
• 全文大小：275 K
• 卷排序：42

文摘

First description of pulmonary disease in immunocompetent patient with a multidrug-resistant Capnocytophaga gingivalis. Acquired resistance to third generation cephalosporins (blaCfxA3), macrolide-lincosamide-streptogramin (erm(F)) and fluoroquinolones. A substitution in QRDR of GyrA (Gly80Asn substitution) was described, for the first time, in Capnocytophaga sp. This multidrug-resistant C. gingivalis isolate illustrated the role of oral flora as a reservoir of antibiotic resistance and its contribution to the limitation of effective antibiotics in severe respiratory infectionsThis multidrug-resistant C. gingivalis isolate illustrated the role of oral flora as a reservoir of antibiotic resistance.