Plantwide design and economic evaluation of two Continuous Pharmaceutical Manufacturing (CPM) cases: Ibuprofen and artemisinin
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- 作者：Hikaru G. Jolliffe ; Dimitrios I. Gerogiorgis ; D.Gerogiorgis@ed.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Continuous Pharmaceutical Manufacturing (CPM) ; Ibuprofen ; Artemisinin ; Process design ; Reactor design ; Separation design
- 刊名：Computers & Chemical Engineering
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：269-288
- 全文大小：5704 K
文摘
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A detailed economic evaluation of two continuous pharmaceutical processes has been performed.
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Two essential Active Pharmaceutical Ingredients (ibuprofen and artemisinin) have been studied.
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Novel upstream flowsheets have been designed on the basis of published continuous flow chemistry.
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Continuous pharmaceutical processes yield considerable cost savings compared to batch processes.
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A sensitivity analysis tackles flowsheet complexity, capacity, prices and separation performance.