Synaptotagmin 2 Is the Fast Ca²⁺ Sensor at a Central Inhibitory Synapse

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• 作者：Chong Chen¹ ; ³ ; Itaru Arai¹ ; ³ ; ⁴ ; Rachel Satterfield² ; Samuel M. Young Jr.² ; Peter Jonas¹ ; ⁵ ; ^{peter.jonas@ist.ac.at}
• 关键词：cerebellum ; basket cells ; transmitter release ; synaptotagmin ; Ca2+ sensor ; exocytosis ; endocytosis ; pool replenishment ; GABAergic synapses ; feedforward inhibition
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：723-736
• 全文大小：4323 K
• 卷排序：18

文摘

Syt2 is the Ca2+ sensor of fast transmitter release at a cerebellar GABAergic synapse Syt2 triggers transmitter release with faster time course than Syt1 Syt2 ensures faster replenishment of the readily releasable pool than Syt1 Syt2 is essential for fast feedforward inhibition in cerebellar microcircuits