Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo

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• 作者：Jian Gan¹ ; Shih-ming Weng¹ ; ² ; ³ ; Alejandro J. Pern&iacute ; a-Andrade¹ ; ⁴ ; Jozsef Csicsvari¹ ; Peter Jonas¹ ; ⁵ ; ^{peter.jonas@ist.ac.at}
• 关键词：sharp wave-ripples ; in vivo recording ; in vivo voltage clamp ; EPSCs ; IPSCs ; hippocampus ; CA1 region ; network oscillations ; PV+ interneurons ; GABAergic synapses
• 刊名：Neuron
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：93
• 期：2
• 页码：308-314
• 全文大小：2674 K
• 卷排序：93

文摘

High-resolution synaptic current recording during sharp wave-ripples (SWRs) in vivo Inhibition dominates over excitation during SWRs in the hippocampal CA1 region Phasic inhibition, but not excitation, is phase-locked to individual ripple cycles PV+ interneurons substantially contribute to SWR-associated inhibitory conductance