Prevalence of left heart contrast in healthy, young, asymptomatic humans at rest breathing room air

详细信息    查看全文

• 作者：Jonathan E. Elliott ; S. Milind Nigam ; Steven S. Laurie ; Kara M. Beasley ; R ; all D. Goodman ; Jerold A. Hawn ; Igor M. Gladstone ; Mark S. Chesnutt ; Andrew T. Lovering
• 关键词：Transthoracic saline contrast echocardiography ; Patent foramen ovale ; Right-to-left shunt ; Intrapulmonary arteriovenous anastomoses
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2013
• 出版时间：1 August, 2013
• 年：2013
• 卷：188
• 期：1
• 页码：71-78
• 全文大小：845 K

文摘

Our purpose was to report the prevalence of healthy, young, asymptomatic humans who demonstrate left heart contrast at rest, breathing room air. We evaluated 176 subjects (18-41 years old) using transthoracic saline contrast echocardiography. Left heart contrast appearing ¡Ü3 cardiac cycles, consistent with a patent foramen ovale (PFO), was detected in 67 (38 % ) subjects. Left heart contrast appearing >3 cardiac cycles, consistent with the transpulmonary passage of contrast, was detected in 49 (28 % ) subjects. Of these 49 subjects, 31 were re-evaluated after breathing 100 % O₂ for 10-15 min and 6 (19 % ) continued to demonstrate the transpulmonary passage of contrast. Additionally, 18 of these 49 subjects were re-evaluated in the upright position and 1 (5 % ) continued to demonstrate the transpulmonary passage of contrast. These data suggest that ¡«30 % of healthy, young, asymptomatic subjects demonstrate the transpulmonary passage of contrast at rest which is reduced by breathing 100 % O₂ and assuming an upright body position.